https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50541 Wed 02 Aug 2023 13:55:11 AEST ]]> Single-cell transcriptomic analysis reveals key immune cell phenotypes in the lungs of patients with asthma exacerbation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46043 + T cells, and macrophages are significantly elevated in the bronchoalveolar lavage fluid of patients. A set of cytokines and intracellular transduction regulators are associated with asthma exacerbations and are shared across multiple cell clusters, forming a complicated molecular framework. An additional group of core exacerbation-associated modules is activated, including eukaryotic initiation factor 2 signaling, ephrin receptor signaling, and C-X-C chemokine receptor type 4 signaling in the subpopulations of CD8+ T cells (C1-a) and monocyte clusters (C7 clusters), which are associated with infection. Conclusion: Our study identified a significant number of severe asthma-associated genes that are differentially expressed by multiple cell clusters.]]> Thu 10 Nov 2022 14:51:33 AEDT ]]>